Phineas And Ferb

It’s a cute show, but it begs the question… What the hell is wrong with the people who live in Phineas and Ferb’s neighborhood? Why don’t they point out to the two boys that they are hideously mutated freaks?

Seriously, why is it that everyone in their universe is totally physically normal except these two, and nobody seems to notice? Phineas has a head shaped loosely like a right angle triangle and Ferb looks sort of like a stick with a can of soup for a nose. And almost everyone else looks normal.

Now, I might be a little bit insane right now because The Demon has been watching the show for the past every second since school ended, and I’m starting to come unhinged, and I get that this might color my experience a little bit, but COME ON! What kind of world do these people live in?

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Cancer Might Just Be In Some Trouble

Great news on some research from a group in Boston! Essentially, what the researchers did was a successful Phase I trial of something called adoptive T-cell therapy, which means that they took T-cells from some people who had advanced melanoma. They then used some genetically engineered antigens that are similar to the ones that the tumor cells possess, and altered the T-cells accordingly. They then increased the number of those T-cells and gave them back to the patient. The end result was extremely promising. You can read the link above, which is a review in greater detail of the process and what it means from the Discovery blog 80beats, or you can read the abstract of the research here.

But the short and skinny of it is that we’re looking at ways to essentially take someone’s T-cells, set the up to beat the hello jello out of their cancer cells, and giving them a boost of their own (slightly modified) immune system cells to fight it off. If this works, then they may well have come up with a concept that can fight off any number of really serious diseases. Of course, we’re hardly out of the woods yet.

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Viral Life On The Enemy’s Payroll

Viruses are jerks. I mean, deep down, that’s their job. They exist solely to infect us. Some of them are theoretically harmless, while others, left unchecked, spell certain doom. However, there have long been theories put forward about friendly viruses, a concept that makes sense on the surface. What if a virus were capable of actually making us fight off other more harmful diseases? What if a virus were used as a delivery mechanism for something beneficial? Where some minds shine is in making the best of a bad situation, and there are plenty of scientists seeking ways to make happy helpers of our viral enemies.

An article I just read from Discovery Magazine’s 80beats blog shows an example of such a possibility. The article, Viruses Show Promise for Creating Drugs By Doing What They Do Best: Evolving explains the work of some researchers at Harvard who are using viruses to optimize proteins to fight particular conditions. That sounds really strange, but as they point out, this is not new science:
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Sam Harris on MSNBC

There are days when I wonder about my own motivations. I’m exceedingly critical of Islam, and that criticalness has more and more been a concern to me. Am I being critical because it is so evil, or is it possibly some darker, more nefarious motivation?

The truth is, Islam is evil. That doesn’t mean that all practitioners of Islam are evil, there are many absolutely wonderful muslims who are good, intelligent, creative people. I have always believed that you judge a person on their deeds and not on their adjectives. But Islam? I’m pretty comfortable saying that Islam is legitimately evil. I would throw all religions I have encountered into the category of evil as well, so at least Islam can’t think I only hate it.

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How Does Your Garden Grow

Evil isn’t an absolute. Let’s face it, with only a handful of exceptions such as child molesting, we can come up with really good arguments to justify the most evil of behaviors. You can’t murder unless it’s in times of war, or for self defence, or to end suffering, or to terminate a pregnancy, or to stop something bad from happening, or because the death of one would save the lives of many. You can’t steal, except to feed your family or get the latest episode of Dexter. Drugs are evil except when they save lives, rebuild economies, or fight crime. There are countless examples, really, and the truth is that morality is almost exclusively not a case of black and white. Morality is judged on a case by case basis, it’s open to interpretation, and no two people are identical in their opinions on what is acceptable or good and what is unacceptable or evil.

Technological advances often get the crap end of the stick with that “evil” label. There are plenty who believe, for example, that the internet is evil simply because there are things on it nobody should want to see. And there are a handful of people in my life that I just simply don’t open email attachments from for that very reason. I didn’t need to see Two Girls One Cup because the first three people who tried to get me to watch it were on my personal No Fly List, and that meant I didn’t want to watch it.

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Please, Sir, Wash The Damned Carrot

I get riled up. I admit it. When a topic that seems to me to be bleeding obvious comes along and stays along, I start to get punchy about it. And today I’m punchy about organic food. I have some friends and some parents (well, two parents to be precise) who will no doubt hate me for saying this, but it matters not. I’m too annoyed. If this offends you, then I’d say do something about it, but no doubt your bodies lack the hormones to rile you up enough to do more than piss in the wind about it.

Organic food is, by and large, a hoax. And it’s a hoax for rich people. I know, you’re thinking, “But I’m not rich! I live on a modest income and make sacrifices for better food.” Yes, you may not be rich in the context of your surroundings, but I’m pretty sure you’ve got amazing buying power next to your average Somali refugee. It’s all in the context, people.

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Sarah Palin – Her Know Science Real Good

I hadn’t really thought much about Sarah Palin’s ridiculous comment about how we should stop spending money on fruit fly research. It was laughable and there were any number of rebuttals presented at the time that showed her for the ignorant boob she is. But I have of late been spending my train rides to and from work listening to a course from MIT that I downloaded from iTunes University on genetics with the incredibly enjoyable instructor, Eric Lander. It’s an introductory course, and it occurred to me that probably most people do not know just how important fruit fly research is. So I figured I’d comment.

It’s not just autism, folks. Yes, in the clip above we see people arguing about the fact that fruit fly research has been integral to the understanding of genetics as a science. People, you see, make a decidedly crappy study medium. With fruit flies, you can control what males and females mate. It’s kind of a big deal, and people are really funny about not letting scientists say “We want to know what color eyes your children will have if you have sex with this woman, so please hop up on the table and get ‘er done.” Fruit flies are much more prolific than people too, so you can see a much clearer picture. If man x and woman y have sex for the purposes of evaluating a phenotopic result, you are statistically not terribly likely to get more than one or two children. Fruit fly ladies can do a hundred in a day. And where human babies take approximately nine months in the mommy to develop and then years to reach adulthood, fruit flies do it in around 10 days (assuming it’s kept at room temperature). The end result there is you can actually study generations of fruit flies efficiently. With people, it’s a whole lot less timely.

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Fear Of The Unknown And The Plight Of The Poor

We as a species are very much defined by the fear of the unknown. This is, for the record, normal, and I’m not in any way advocating that we stop being afraid of the unknown. One of the things that has led to our survival as a species and as individuals is selectively listening to that fear. But at the same time, we have (or should have) a thirst for knowledge that leads the unknown to become knowable. Where does the line exist? I’d be a fool to speculate.

Religion comes in large part from fear of the unknown. When we are presented with things we do not know, it is easy to turn to a god figure who will answer the question for us. What happens when we die? Why did the volcano erupt? Why did the crops this season do so well? All of these questioned we have traditionally answered with religion and with an emphasis on how well we have behaved. But that’s just one example of how we deal with this fear of the unknown.

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